Psoralen and UVA inactivation

Ufo LED Grow Lights 200 Watt Ip65,Psoralen is a natural furanocoumarin derived from a plant in Egypt called the great Amish hemsley. They are also found in celery, parsley, carrots, parsnips and other vegetables.Exposure to the sun after eating these foods has been known since ancient times to cause a photosensitive skin reaction similar to sunburn.


In 1982, malaytea scurfpea fruit, combined with UVA light (PUVA) and began to be used in the treatment of psoriasis (commonly known as psoriasis is a chronic inflammatory skin disease) and patients with oral scurfpea fruit element compounds or when in the bath malaytea scurfpea fruit, under the stimulus of UVA, malaytea scurfpea fruit, can promote the synthesis of melanin, make its deposit on the skin, thus effectively in the treatment of vitiligo, psoriasis and other skin diseases.


The psoralen molecule has the right structure and shape to insert between the two strands of DNA in the double helix structure and induce the formation of interstrand covalent cross-linking between the reverse complementary nucleic acid chains under light, thus damaging the DNA structure.Thus, PUVA has been used to inactivate bacteria, viruses and protozoa in platelets and plasma blood components.


The photochemical inactivation activity of PUVA can kill the pathogen while maintaining its metabolic capacity (KBMA), which means that this method can inactivate the whole microorganism.


But still maintain its immunogenicity, so it can be used for vaccine development.Several research teams have developed recombinant and pathogene-derived KBMA vaccines using intact individuals of microorganisms that have been shown to be harmless and immunogenicity, a technique that offers new hope for the prevention of specific diseases and the reduction of infectious diseases in animal models.In addition, PUVA can also be used to inactivate a variety of other viruses, such as dengue virus, chikungunya virus, sars-cov, etc.


Some researchers use acid lime and synthetic psoraleae to enhance the sun's ability to disinfect water.They evaluated the norovirus, escherichia coli and MS2 bacteriophages in the lab and found that psoralen and acid lime extract, in conjunction with ultraviolet radiation, can accelerate microbial inactivation.

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